Folate Receptor (FR)
Folate Receptor (FR)
Folate receptor (FR) is a class of cysteine-rich glycosylphosphatidylinositol-coupled protein that can mediate folate transport from outside to inside cells, and is divided into FR-α, FR-β, and FR-γ Subtypes. FR-α is expressed in renal proximal tubules and in various solid epithelial neoplasms (ovary, endometrium, brain, lung, and renal cancers). FR-β is expressed in normal hematopoietic tissue, activated macrophages, and hematogenous malignancies. Folate receptor can be used for the early diagnosis and study of tumors[1]sup>[2].
Folate Receptor (FR) Isoform Specific Products
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Folate Receptor (FR) Related Products (29)
Related Products (29)
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Folate Receptor (FR) Isoform Comparison
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DBCO-PEG2000-FA
0 ImagesCat. No.: HY-W1123936CSynonyms: DBCO-PEG2000-FolateDBCO-PEG2000-FA (DBCO-PEG2000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folate receptors (FR). Folate receptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications.
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Pteropterin monohydrate
0 ImagesCat. No.: HY-127118ACAS No.: 6164-84-7Synonyms: Pteroyltriglutamic monohydratePteropterin (Pteroyltriglutamic) monohydrate is an active form of folate. Pteropterin monohydrate shows inhibiting effect on tumor growth and has broad anticancer activity.
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Farletuzumab-LNK4-S (DAR8)
0 ImagesCat. No.: HY-185773Farletuzumab-LNK4-S (DAR8) is an antibody-drug conjugate (ADC) with a drug-to-antibody ratio of 8. Farletuzumab-LNK4-S (DAR8) is conjugated from the anti-FRα antibody Farletuzumab (HY-P99153) and LNK4-S (HY-170400). Farletuzumab-LNK4-S (DAR8) can be used in cancer-related research.
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Etarfolatide
0 ImagesCat. No.: HY-13616CAS No.: 479578-27-3Synonyms: EC 20Etarfolatide (EC 20) is a valuable noninvasive imaging agent. Etarfolatide identifies folate receptor expression. Etarfolatide can be used in research on ovarian cancer and disease diagnosis after being radiolabeled.
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KHK2805
0 ImagesCat. No.: HY-P992004Synonyms: RA15-7, HuRA15-7AccKHK2805 (RA15-7) is a humanized antibody against folate receptor α (FOLR1), with a Kd of 0.647 nM for human FOLR1. KHK2805 binds to a unique epitope of FOLR1 and mediates antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity against FOLR1-expressing cells. KHK2805 exhibits cytotoxicity against both ovarian cancer cells and Platinum (HY-W096169D)-resistant ovarian cancer cells. KHK2805 can be used for the research of tumors such as ovarian cancer.
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DBCO-PEG5000-FA
0 ImagesCat. No.: HY-W1123936ESynonyms: DBCO-PEG5000-FolateDBCO-PEG5000-FA (DBCO-PEG5000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folate receptors (FR). Folate receptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications.
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Sofetabart
0 ImagesSynonyms: LY-4170156 Antibody; MBK-103 AntibodySofetabart (LY-4170156 Antibody) is a humanized IgG1 antibody that specifically targets folate receptor α (FRα). Sofetabart can be used to synthesize the antibody-drug conjugate (ADC) Sofetabart mipitecan. Sofetabart is applicable to research related to advanced ovarian cancer, platinum-resistant epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer, as well as platinum-sensitive ovarian cancer.
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(4-Aminobenzoyl)-D-glutamic acid
0 ImagesCat. No.: HY-W713855CAS No.: 5959-18-2(4-Aminobenzoyl)-D-glutamic acid (Compound 17) exhibits competitive inhibitory activity against H2-pteroate synthesis system, which affects the synthesis of folate, thereby inhibiting growth of bacteria.
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Cy3-PEG2000-FA
0 ImagesCat. No.: HY-D2523Cy3-PEG2000-FA is a fluorescent folate-PEG derivative with excitation/emission wavelengths of ~550 nm/~570 nm. Cy3-PEG2000-FA can be readily traced by its intense red fluorescent signal. Cy3-PEG2000-FA can be used for cell imaging, folate receptor targeting and detection.
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